Heterocycles

Biotransformation of phenyl-and pyridylalkane derivatives in rat liver 9,000 xg supernatant (S-9)

M Takeshita, M Miura, Y Unuma, S Iwai, I Sato…

Index: Heterocycles, , vol. 42, # 2 p. 831 - 836

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Citation Number: 3

Abstract

... The oxidation of pyridylalkane was significantly inhibited by cytochrome P-450 inhibitor (SKF-525A), but reduction of acetylpyridines was not inhibited. Thus, cytochrome P-450 was found to be responsible for the oxidation... ...

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