Natural Product Research 2012-01-01

Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.

Pham Huu Dien, Nguyen Thi Nhan, Hoang Thi Le Thuy, Dang Ngoc Quang

Index: Nat. Prod. Res. 26(22) , 2107-11, (2012)

Full Text: HTML

Abstract

From the ethyl acetate extract of the seeds of Vietnamese Cnidium monnieri L., three coumarins, osthole (1), xanthotoxin (2), imperatorin (3) and a sterol, daucosterol (4) have been purified. Their structures were elucidated by spectroscopic analysis. Furthermore, 8-(3-hidroxy-3-methylbutyl)-7-methoxycoumarin (5) was synthesised from osthole (1) with a good yield (80%). In addition, compound 1 and its synthesis product (5) show moderate and non-selective cytotoxic activities against four cancer cells, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma).

Related Compounds

  • Daucosterol
  • Imperatorin

Related Articles:

[Chemical constituents contained in seeds of Notopterygium franchetii].

2012-04-01

[Zhongguo Zhong Yao Za Zhi 37(7) , 941-5, (2012)]

[Study on the chemical constituets in ethyl acetante extraction from semen litchi].

2012-01-01

[Zhong Yao Cai 35(1) , 64-6, (2012)]

[Chemical constituents from stems of Dysoxylum laxiracemosum].

2012-05-01

[Zhongguo Zhong Yao Za Zhi 37(9) , 1237-40, (2012)]

[Study on the chemical constituents from Cyathea spinulosa].

2012-04-01

[Zhong Yao Cai 35(4) , 568-70, (2012)]

[Studies on the chemical constituents from Cissus pteroclada].

2010-10-01

[Zhong Yao Cai 33(10) , 1566-8, (2010)]

More Articles...