Large hydrophobic interactions with clearly defined geometry. A dimeric steroid with catalytic properties

…, RS McDonald, S O'Leary

Index: Guthrie, J. Peter; Cullimore, Patricia A.; McDonald, Robert S.; O'Leary, Stella Canadian Journal of Chemistry, 1982 , vol. 60, p. 747 - 764

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Citation Number: 22

Abstract

The steroid dimer α, α'-bis (17β-(4'-imidazolyl)-11-keto-5α-androstan-3β-amino)-p-xylene, 3, has been synthesized by reductive animation of 17β-(4'-imidazolyl)-5α-androstane-3, 11- dione by p-xylenediamine in the presence of sodium cyanoborohydride, and by reductive amination of terephthalaidehyde by 3β-amino-17β-(4'-imidazolyl)-5α-androstan-11-one. The second method is stereochemically unambiguous; the first is not. Compound 3 acts as a ...

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