Journal of the American Chemical Society 2004-01-28

Thermal stability of the secondary structure of poly(alpha,L-glutamate) in self-assembled complexes as studied by molecular dynamics in chloroform solution.

David Zanuy, Jordi Casanovas, Carlos Alemán

Index: J. Am. Chem. Soc. 126 , 704-705, (2004)

Full Text: HTML

Abstract

The thermal stability of the self-assembled complexes formed by alkyltrimethylammonium surfactants and poly(alpha,l-glutamate) is investigated in dilute chloroform solution by molecular dynamics simulations. By applying temperatures ranging from 300 to 500 K, we observed an extraordinary stability of the alpha-helix adopted by the polypeptide during a total of 48 ns. The multiple electrostatic interactions formed between the surfactant chains and the polyanion play a crucial role in this stability since they are responsible for the inaccessibility of the solvent molecules to the helix even at high temperatures.

Related Compounds

  • POLY-D-GLUTAM...

Related Articles:

Spiral superstructures of amyloid-like fibrils of polyglutamic acid: an infrared absorption and vibrational circular dichroism study.

2011-09-22

[J. Phys. Chem. B 115 , 11010-11016, (2011)]

Administration of poly-D-glutamic acid induces proliferation of erythropoietin-producing peritubular cells in rat kidney.

2007-02-01

[Am. J. Physiol. Renal Physiol. 292 , F749-761, (2007)]

Chirality and helix stability of polyglutamic acid enantiomers.

2008-03-01

[J. Colloid. Interface Sci. 319 , 72-80, (2008)]

Polyelectrolyte multilayer capsules with quantum dots for biomedical applications. Adamczak M, Hoel HJ, Gaudernack G, et al.

[Colloids Surf., B 90 , 211-216, (2012)]

More Articles...