Archives of Biochemistry and Biophysics 2014-02-15

Nickel-dependent metalloenzymes.

Jodi L Boer, Scott B Mulrooney, Robert P Hausinger

Index: Arch. Biochem. Biophys. 544 , 142-52, (2014)

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Abstract

This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase. These enzymes catalyze their various chemistries by using metallocenters of diverse structures, including mononuclear nickel, dinuclear nickel, nickel-iron heterodinuclear sites, more complex nickel-containing clusters, and nickel-tetrapyrroles. Selected other enzymes are active with nickel, but the physiological relevance of this metal specificity is unclear. Additional nickel-containing proteins of undefined function have been identified. Copyright © 2013 Elsevier Inc. All rights reserved.

Related Compounds

  • Nickel
  • Glyoxalase I, fro...
  • Urea

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