Efficient synthesis of imidazoles from aldehydes and 1, 2-diketones using microwave irradiation
SE Wolkenberg, DD Wisnoski, WH Leister…
Index: Wolkenberg, Scott E.; Wisnoski, David D.; Leister, William H.; Wang, Yi; Zhao, Zhijian; Lindsley, Craig W. Organic Letters, 2004 , vol. 6, # 9 p. 1453 - 1456
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Citation Number: 338
Abstract
A simple, high-yielding synthesis of 2, 4, 5-trisubstituted imidazoles from 1, 2-diketones and aldehydes in the presence of NH4OAc is described. Under microwave irradiation, alkyl-, aryl- , and heteroaryl-substituted imidazoles are formed in yields ranging from 80 to 99%. Short syntheses of lepidiline B and trifenagrel illustrate the utility of this approach.
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