Life Sciences 2014-04-25

BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip1

Gun-Hee Jang, Michael Lee

Index: Life Sci. 102(1) , 41-8, (2014)

Full Text: HTML

Abstract

Aims The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors.

Related Compounds

  • Gossypol
  • AT-101

Related Articles:

Male contraception: history and development.

2014-02-01

[Urol. Clin. North Am. 41(1) , 145-61, (2014)]

The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs.

2014-04-01

[Br. J. Haematol. 165(1) , 78-88, (2014)]

(-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes.

2013-03-01

[Anticancer Res. 33(3) , 949-55, (2013)]

Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol.

2013-04-01

[Acta Crystallogr. C 69(Pt 4) , 439-43, (2013)]

Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo.

2013-11-01

[Leukemia 27(11) , 2262-4, (2013)]

More Articles...