Synthesis and reactions of 2??chloro??3, 4??dihydrothienopyrimidines and??quinazolines

H Yamaguchi, F Ishikawa

Index: Yamaguchi, Hitoshi; Ishikawa, Fumiyoshi Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 67 - 70

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Citation Number: 15

Abstract

Abstract Reaction of 2, 4-dichlorothienopyrimidines and-quinazolines 1 with sodium borohydride gave the corresponding 2-chloro-3, 4-dihydro derivatives 2. Some nucleophilic substitutions of 2b afforded 2-substituted derivatives 3b-7b and reaction of 2g, h with ethyl bromoacetate yielded selectively the corresponding 3-substituted compounds 8g, h which were derived to imidazo [2, 1-b] quinazolin-2-ones 9g, h.