Biological & Pharmaceutical Bulletin 2004-07-01

Passive cutaneous anaphylaxis-inhibitory action of tectorigenin, a metabolite of tectoridin by intestinal microflora.

Eun-Kyung Park, Yong-Wook Shin, Hae-Ung Lee, Chang Soo Lee, Dong-Hyun Kim

Index: Biol. Pharm. Bull. 27(7) , 1099-102, (2004)

Full Text: HTML

Abstract

Tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae) are metabolized to tectorigenin by human intestinal microflora. When tectoridin was orally administered to rats, tectorigenin, but not tectoridin, was detected in urine after beta-glucuronidase hydrolysis. The main metabolite tectorigenin potently inhibited the passive cutaneous anaphylaxis reaction and inhibited in vitro the release of beta-hexosaminidase from RBL-2H3 cells induced by IgE. These results suggest that tectoridin is a prodrug, which can be transformed into the active agent tectorigenin by human intestinal bacteria and can be a candidate for antiallergic agent.

Related Compounds

  • tectoridin

Related Articles:

Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells.

2008-11-01

[Arch. Pharm. Res. 31(11) , 1447-56, (2008)]

Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.

2009-03-31

[Mol. Cells 27(3) , 351-7, (2009)]

Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains.

2009-07-01

[J. Nat. Med. 63(3) , 254-60, (2009)]

Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia.

2009-06-01

[J. Asian Nat. Prod. Res. 11(6) , 471-81, (2009)]

Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats.

2004-02-01

[Arch. Pharm. Res. 27(2) , 184-8, (2004)]

More Articles...