Organic Letters 2012-11-16

α-Aryl-substituted allenamides in an imino-Nazarov cyclization cascade catalyzed by Au(I).

Zhi-Xiong Ma, Shuzhong He, Wangze Song, Richard P Hsung

Index: Org. Lett. 14(22) , 5736-9, (2012)

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Abstract

An imino-Nazarov cyclization using α-aryl-substituted allenamides is described. This gold(I)-catalyzed cascade is efficient and regioselective in constructing a diverse array of synthetically useful aromatic-ring fused cyclopentenamides. The success in this transformation represents a solution to the challenge in establishing an imino-Nazarov cyclization process.

Related Compounds

  • Gold(III) chlori...
  • Gold (I) chloride

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