Tetrahedron

Synthesis of 3′-azido-and 3′-amino-3′-deoxyadenosine in both enantiomeric forms

O Botta, E Moyroud, C Lobato, P Strazewski

Index: Botta, Oliver; Moyroud, Elisabeth; Lobato, Cinta; Strazewski, Peter Tetrahedron, 1998 , vol. 54, # 44 p. 13529 - 13546

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Citation Number: 17

Abstract

Aminosugar nucleosides are important bioactive molecules of which puromycin, a derivative of 3′-amino-3′-deoxyadenosine, is one of the most important examples. Some azidosugar nucleosides, the synthetic precursors of the corresponding aminosugar compounds, are known to be active against HIV reverse transcriptase. We are interested in comparing the bioactivity of D-and L-enantiomers of such nucleosides. Here, the synthesis ...

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