Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy

YH Wang, HW Yeh, HW Wang, CC Yu, JH Guh…

Index: Wang, Ying-Hsin; Yeh, Hsien-Wei; Wang, Hsiao-Wen; Yu, Chia-Chun; Guh, Jih-Hwa; Liu, Der-Zen; Liang, Pi-Hui Carbohydrate Research, 2013 , vol. 375, p. 118 - 135

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Citation Number: 9

Abstract

Naturally occurring spirostanol saponins bear a chacotriose, α-l-rhamnopyranosyl-(1→ 2)-[α- l-rhamnopyranosyl-(1→ 4)]-β-d-glucopyranose residue as the oligosaccharide moiety which is believed to be important for biological activity. Herein the development of a concise, combinatorial method for the synthesis of two series of glycan variants at the 2′ and/or 4′ positions of chacotriose is described and the structure–activity relationships of the glycone ...