Toxicology Letters 2013-11-25

Crotonaldehyde induces heat shock protein 72 expression that mediates anti-apoptotic effects in human endothelial cells

Dong Sun Ryu, Hana Yang, Seung Eun Lee, Cheung-Seog Park, Young-Ho Jin, Yong Seek Park

Index: Toxicol. Lett. 223(2) , 116-23, (2013)

Full Text: HTML

Abstract

• Crotonaldehyde induces HSP72 up-regulation in HUVECs. • HSP72 induction is mediated by JNK-HSF1 pathway. • HSP72 expression by crotonaldehyde requires calcium ions and ROS. • Up-regulation of HSP72 protects against crotonaldehyde-induced apoptosis in HUVECs.

Related Compounds

  • EGTA
  • Crotonaldehyde
  • BAPTA
  • Crotonaldehyde

Related Articles:

Functional consequence of the MET-T1010I polymorphism in breast cancer.

2015-02-20

[Oncotarget 6(5) , 2604-14, (2015)]

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.

2014-01-01

[PLoS ONE 9(12) , e116152, (2014)]

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.

2015-05-01

[Biomaterials 51 , 1-11, (2015)]

Effect of (2)H and (18)O water isotopes in kinesin-1 gliding assay.

2014-01-01

[PeerJ 2 , e284, (2014)]

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.

2014-01-01

[Nat. Commun. 5 , 5491, (2014)]

More Articles...