Synthesis and biological activities of pseudopeptide analogs of the C-terminal heptapeptide of cholecystokinin. On the importance of the peptide bonds
…, MC Galas, P Fulcrand, C Mendre…
Index: Rodriguez, Marc; Lignon, Marie-Francoise; Galas, Marie-Christine; Fulcrand, Pierre; Mendre, Christiane; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1366 - 1373
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Citation Number: 44
Abstract
A series of pseudopeptide analogues of the C-terminal heptapeptide of cholecystokinin in which each peptide bond, one at a time, has been replaced by a CH2NH bond were synthesized: Z-Tyr (S03-)-Nle-Gly-Trp-Nle-Asp $-(CHzNH) P he-NH2 (1 1, Z-Tyr (SO,-)-Nle- Gly-Trp-Nle $(CH2NH) Asp-Phe-NH2 (2), Z-Tyr (SO,-)-Nle-Gly-Trp $-
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