Pyrido [2, 3-d] pyrimidine angiotensin II antagonists

JW Ellingboe, M Antane, TT Nguyen…

Index: Ellingboe, John W.; Antane, Madelene; Nguyen, Thomas T.; Collini, Michael D.; Antane, Schuyler; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 542 - 550

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Citation Number: 44

Abstract

A series of pyrido [2, 3-d] pyrimidine angiotensin I1 (A 11) antagonists was synthesized and tested for antagonism of A 11. Compounds with a biphenylyltetrazole pharmacophore and small alkyl groups at the 2-and 4-positions of the pyridopyrimidine ring were found to be the most potent in an AT1 receptor binding assay and in blocking the A I1 pressor response in anesthetized, ganglionblocked A 11-infused rats. 5, 8-Dihydro-2, 4-dimethyl-8-[(2'-(1H- ...