European Journal of Organic Chemistry

Microwave??Assisted Synthesis of Polysubstituted 4??Quinolones from Deprotonated α??Aminonitriles

A Romek, T Opatz

Index: Romek, Alexandra; Opatz, Till European Journal of Organic Chemistry, 2010 , # 30 p. 5841 - 5849

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Citation Number: 13

Abstract

Abstract The α-alkylation of deprotonated N-aryl-α-aminonitriles with α-bromoesters furnishes intermediates that can be cyclized to 4-quinolones upon microwave irradiation. Alternatively, base-induced dehydrocyanation of the alkylation products furnishes enaminoesters, which can, for example, be converted into quinoline-3-carboxylates.