Chemical Communications 2010-04-14

Diastereoselective HOTf-catalyzed three-component one-pot 1,3-dipolar cycloaddition of alpha-diazo ester, nitrosobenzene and electron-deficient alkene.

Zhen-Jiang Xu, Di Zhu, Xiaofei Zeng, Fei Wang, Bin Tan, Yuxuan Hou, Yunbo Lv, Guofu Zhong

Index: Chem. Commun. (Camb.) 46(14) , 2504-6, (2010)

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Abstract

A novel HOTf-catalyzed three-component one-pot cycloaddition of alpha-diazo ester, nitrosobenzene and electron deficient alkene has been developed. This catalysis is very simple to operate and tolerant to moisture/oxygen to afford the product with high to excellent diastereoselectivity in good to excellent yield, thus providing a useful and convenient method for the preparation of diverse functionalized isoxazolidines under very mild conditions.

Related Compounds

  • Nitrosobenzene

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