FEBS Letters 1999-12-03

Metabolite transport in isolated yeast mitochondria: fumarate/malate and succinate/malate antiports.

M L Pallotta, A Fratianni, S Passarella

Index: FEBS Lett. 462(3) , 313-6, (1999)

Full Text: HTML

Abstract

In this study, we investigated the metabolite permeability of isolated coupled Saccharomyces cerevisiae mitochondria. The occurrence of a fumarate/malate antiporter activity was shown. The activity differs from that of the dicarboxylate carrier (which catalyses the succinate/malate antiport) in (a) kinetics (Km and Vmax values are about 27 microM and 22 nmol min(-1) mg protein(-1) and 70 microM and 4 nmol min(-1) mg protein(-1), respectively), (b) sensitivity to inhibitors, (c) Ki for the competitive inhibitor phenylsuccinate and (d) pH profiles.

Related Compounds

  • Phenylsuccinic aci...

Related Articles:

Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial l-lactate uptake/metabolism and oxaloacetate export via novel L-lactate translocators.

2004-05-15

[Biochem. J. 380(Pt 1) , 231-42, (2004)]

The influence of the molecular system on the performance of heteronuclear decoupling in solid-state NMR.

[J. Magn. Reson. 210(1) , 75-81, (2011)]

Fumarate permeation in rat liver mitochondria: fumarate/malate and fumarate/phosphate translocators.

1985-10-15

[Biochem. Biophys. Res. Commun. 132(1) , 8-18, (1985)]

Carrier-mediated transport controls hydroxyproline catabolism in heart mitochondria from spontaneously hypertensive rat.

1996-11-04

[FEBS Lett. 396(2-3) , 279-84, (1996)]

Synthesis, characterization and cytotoxicity of diam(m)-ineplatinum(II) complexes containing beta-phenylisosuccinate ligand.

2007-11-01

[Arch. Pharm. (Weinheim) 340(11) , 599-602, (2007)]

More Articles...