Tetrahedron Letters

First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles

G Cusati, L Djakovitch

Index: Cusati, Giuseppe; Djakovitch, Laurent Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2499 - 2502

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Citation Number: 67

Abstract

A simple heterogeneously palladium-catalysed procedure for the selective C3-arylation of indoles is reported. Under relatively standard reaction conditions (Pd-catalyst, K2CO3, dioxane, reflux), using only 1mol%[Pd (NH3) 4]/NaY as the catalyst, indoles substituted or not at position 2 gave up to 92% conversion (ie, 85% isolated yield) towards the expected C3-arylated indole.

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