Brain Research 1997-05-30

17alpha-Dihydroequilenin increases hippocampal dendritic spine density of ovariectomized rats.

S A Washburn, C E Lewis, J E Johnson, M L Voytko, C A Shively

Index: Brain Res. 758(1-2) , 241-4, (1997)

Full Text: HTML

Abstract

The effects of estradiol and 17alpha-dihydroequilenin on the apical dendrite spine density of pyramidal cells of the CA1 region of rat hippocampus were compared. 17alpha-Dihydroequilenin was as effective as estradiol in increasing spine densities relative to controls. 17alpha-Dihydroequilenin is not uterotrophic like estradiol but does have beneficial effects on the cardiovascular system, suggesting that it may be an effective single-agent hormone replacement therapy to treat menopausal symptoms and reduce chronic disease risk in menopausal women.

Related Compounds

  • estra-1,3,5(10),7-...

Related Articles:

Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition.

2003-09-01

[Climacteric 6(3) , 221-7, (2003)]

Ozonation of a mixture of estrogens and progestins in aqueous solution: interpretation of experimental results by computational methods.

2012-11-01

[Chemosphere 89(11) , 1323-9, (2012)]

Free synthetic and natural estrogen hormones in influent and effluent of three municipal wastewater treatment plants.

2007-09-01

[Water Environ. Res. 79(9) , 969-74, (2007)]

Determination of 17 alpha-dihydroequilenin in rat, rabbit and monkey plasma by high-performance liquid chromatography with fluorimetric detection.

1996-02-09

[J. Chromatogr. B, Biomed. Appl. 676(1) , 69-75, (1996)]

Biologic effects of 17 alpha-dihydroequilin sulfate.

1996-11-01

[Fertil. Steril. 66(5) , 748-52, (1996)]

More Articles...