Bioorganic & Medicinal Chemistry Letters 2005-07-01

Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.

Vishnu K Tandon, Dharmendra B Yadav, Ashok K Chaturvedi, Praveen K Shukla

Index: Bioorg. Med. Chem. Lett. 15 , 3288-91, (2005)

Full Text: HTML

Abstract

A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats.

Related Compounds

  • Naphthazarin

Related Articles:

Stimulation of Suicidal Erythrocyte Death by Naphthazarin.

2015-12-01

[Basic Clin Pharmacol Toxicol. 117 , 369-74, (2016)]

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

2009-03-15

[Bioorg. Med. Chem. 17 , 2276-81, (2009)]

Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells.

2015-04-01

[Int. J. Oncol. 46(4) , 1659-66, (2015)]

Inhibitory effect of a naphthazarin derivative, S64, on heat shock factor (Hsf) activation and glutathione status following hypoxia.

2003-10-01

[Cell Biol. Toxicol. 19(5) , 273-84, (2003)]

Effect of colloidal silver against the cytotoxicity of hydrogen peroxide and naphthazarin on primary cultured cortical astrocytes.

2007-03-01

[Int. J. Neurosci. 117(3) , 387-400, (2007)]

More Articles...