Journal of Asian Natural Products Research 2007-01-01

Microbial transformation of neoandrographolide by Aspergillus niger (AS 3.739).

Li-Xia Chen, Feng Qiu, Ge-Xia Qu, Xin-Sheng Yao

Index: J. Asian Nat. Prod. Res. 9(3-5) , 463-9, (2007)

Full Text: HTML

Abstract

The biotransformation of neoandrographolide (1) was investigated by using Aspergillus niger (AS 3.739). Five products were obtained and identified as 8(17),13-ent-labdadien-16,15-olid-19-oic acid (2), 19-hydroxy-8(17),13-ent-labdadien-16,15-olide (3), 18-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (4), 3alpha-hydroxy-8(17),13-ent-labdadien-16,15-olid-19-oic acid (5) and 8beta,19-dihydroxy-ent-labd-13-en-16,15-olide (6) by spectroscopic and chemical means. Products 4, 5 and 6 are new compounds.

Related Compounds

  • Neoandrographolide

Related Articles:

Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata.

1993-07-06

[Biochem. Pharmacol. 46(1) , 182-5, (1993)]

Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression.

2010-11-01

[Int. Immunopharmacol. 10(11) , 1361-73, (2010)]

Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.

2012-11-01

[J. Pharm. Biomed. Anal. 70 , 87-93, (2012)]

Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E2 production in LPS-stimulated murine macrophage.

2007-04-01

[Mol. Cell Biochem. 298(1-2) , 49-57, (2007)]

Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.

1999-02-15

[Biochem. J. 338 ( Pt 1) , 107-13, (1999)]

More Articles...