Pharmacology & Therapeutics 1991-01-01

The biochemical pharmacology of nogalamycin and its derivatives.

L H Li, W C Krueger

Index: Pharmacol. Ther. 51(2) , 239-55, (1991)

Full Text: HTML

Abstract

This review assimilates up-to-date information on the biochemical pharmacology of nogalamycin and selected derivatives that have shown good biological activities and/or received a relatively detailed investigation. The structure and chemical preparation of these derivatives from nogalamycin is described and the nomenclature which has been rather perplexing in the literature is clarified. The interaction of this class of compounds, particularly nogalamycin, with DNA is extensively reviewed. The biochemical mechanism of action of nogalamycin and its structurally closely-related derivatives is described. Among nogalamycin derivatives, menogaril showed distinct biochemical effects as well as superior cytotoxicity and antitumor activity and also proved to be effective against breast cancer clinically.

Related Compounds

  • Nogalamycin

Related Articles:

Kinetic characterization of small DNA-binding molecules interacting with a DNA strand on a quartz crystal microbalance.

2016-01-01

[Anal. Biochem. 492 , 34-42, (2015)]

The intercalation of DNA double helices with doxorubicin and nogalamycin.

2007-07-01

[J. Mol. Graph. Model. 26(1) , 14-9, (2007)]

Engineering anthracycline biosynthesis toward angucyclines.

2003-04-01

[Antimicrob. Agents Chemother. 47(4) , 1291-6, (2003)]

Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.

2009-03-01

[Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 3) , 256-9, (2009)]

Influence of initial charge state on fragmentation patterns for noncovalent drug/DNA duplex complexes.

2005-10-01

[J. Mass Spectrom. 40(10) , 1362-71, (2005)]

More Articles...