The synthesis and activity of some 2, 6-difluorophenyl-substituted compounds

AM Roe, RA Burton, GL Willey…

Index: Journal of Medicinal Chemistry, , vol. 11, # 4 p. 814 - 819

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Citation Number: 37

Abstract

... Chem. Sac., 68, 1386 (1946). t tr .4rOH ArCHO -+- ArCH2OH ArCOlIe + ArLi -+- ArI 11; I t J. ... Thi. is possible in the traiisitioii btate for the formation of 4-chloro-2-fluoro- nitrobenzene sirice the chlorine atom has moved out of the ~)lanc> of the ring. Ho~vever, rieither 2-chloro-l- ...