Bioorganic & Medicinal Chemistry Letters 2004-11-01

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Binoy Jose, Yusuke Oniki, Tamaki Kato, Norikazu Nishino, Yuko Sumida, Minoru Yoshida

Index: Bioorg. Med. Chem. Lett. 14(21) , 5343-6, (2004)

Full Text: HTML

Abstract

Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.

Related Compounds

  • 1-Bromo-3,3,3-trif...

Related Articles:

Conformational change study of dengue virus NS2B-NS3 protease using (19)F NMR spectroscopy.

2015-06-12

[Biochem. Biophys. Res. Commun. 461 , 677-80, (2015)]

Actin dynamics studied by solid-state NMR spectroscopy.

1991-01-01

[Eur. Biophys. J. 19(3) , 147-55, (1991)]

Substituted trifluoroketones as potent, selective inhibitors of mammalian carboxylesterases.

1987-06-15

[Biochem. Pharmacol. 36(12) , 1869-79, (1987)]

19F nuclear magnetic resonance studies of selectively fluorinated derivatives of G- and F-actin.

1986-04-22

[Biochemistry 25(8) , 2187-91, (1986)]

Interaction between G-actin and various types of liposomes: A 19F, 31P, and 2H nuclear magnetic resonance study.

1998-03-03

[Biochemistry 37(9) , 3149-55, (1998)]

More Articles...