Journal of the American Chemical Society 2005-08-03

Kinetic resolution of axially chiral 2,2'-dihydroxy-1,1'-biaryls by palladium-catalyzed alcoholysis.

Hiroshi Aoyama, Makoto Tokunaga, Junya Kiyosu, Tetsuo Iwasawa, Yasushi Obora, Yasushi Tsuji

Index: J. Am. Chem. Soc. 30th ed., 127 , 10474-10475, (2005)

Full Text: HTML

Abstract

Palladium-diamine complexes catalyzed kinetic resolution of axially chiral 2,2'-dihydroxy-1,1'-biaryls by alcoholysis of vinyl ethers. The reaction proceeded with high selectivity for various kinds of biaryls. This process is applicable to not only binaphthols but also biphenols, which have been considered to be difficult for the enantioselective synthesis by known catalytic methods.

Related Compounds

  • Vinylboronic anhyd...

Related Articles:

Transition metal-catalyzed synthesis and reactivity of N-alkenyl aziridines.

2005-03-17

[Org. Lett. 6th ed., 7 , 1161-1164, (2005)]

Stereoselective isomerisation of N-allyl aziridines into geometrically stable Z enamines by using rhodium hydride catalysis.

2008-01-01

[Chemistry 3rd ed., 14 , 886-894, (2008)]

The alkyl-connected 2-amino-6-vinylpurine (AVP) crosslinking agent for improved selectivity to the cytosine base in RNA

2010-01-01

[Bioorg. Med. Chem. 8th ed., 18 , 2894-2901, (2010)]

Efforts toward distorted spiropentanes.

2010-11-05

[J. Org. Chem. 21th ed., 75 , 7494-7497, (2010)]

Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.

2011-04-01

[Bioorg. Med. Chem. Lett. 7th ed., 21 , 1942-1947, (2011)]

More Articles...