Effect of tyrosine on brain catecholamine turnover in reserpine-treated rats.

T Oishi, R J Wurtman

Index: J. Neural Transm. Gen. Sect. 53(2-3) , 101-8, (1982)

Full Text: HTML

Abstract

The injection of reserpine [2.5 mg/kg, intraperitoneally (i.p.)] increased brain concentration of tyrosine and of the major catecholamine metabolites, 3-methoxy-4-hydroxy-phenylethylene--glycol-sulfate (MHPG-SO4) in the rat. In reserpine-treated animals, tyrosine administration (200 mg/kg, i.p.) caused further increases in brain tyrosine, DOPAC, and HVA, but not in brain MHPG-SO4. The increases in DOPAC and HVA levels were observed in a dopaminergic brain region (the corpus striatum) and a noradrenergic region (the cerebellum). These results support previous observations that catecholamine synthesis and release in both dopaminergic and noradrenergic neurons can depend in part upon brain tyrosine levels.

Related Compounds

  • 3-Hydroxy-4-methox...

Related Articles:

Determination of 4-O-methylated catecholamine metabolites in urine by mass fragmentography.

1979-10-01

[Clin. Chem. 25(10) , 1708-13, (1979)]

Levels of dopamine and 3,4-dihydroxyphenylacetic acid in the adenohypophysis of normo- and hypertensive rats.

1990-01-01

[Clin. Exp. Hypertens. A. 12(3) , 343-53, (1990)]

Determination of homovanillic, isohomovanillic and vanillylmandelic acids in human urine by means of glass capillary gas-liquid chromatography with temperature-programmed electron-capture detection.

[J. Chromatogr. A. 183(4) , 391-401, (1980)]

More Articles...