Fluoroanalogs of DDT: superacidic BF3–H2O catalyzed facile synthesis of 1, 1, 1-trifluoro-2, 2-diarylethanes and 1, 1-difluoro-2, 2-diarylethanes

GKS Prakash, F Paknia, T Mathew, G Mlostoń…

Index: Prakash, G. K. Surya; Paknia, Farzaneh; Mathew, Thomas; Mloston, Gzregorz; Joschek, Jens P.; Olah, George A. Organic Letters, 2011 , vol. 13, # 15 p. 4128 - 4131

Full Text: HTML

Citation Number: 24

Abstract

The one-pot synthesis of 1, 1, 1-trifluoro-and 1, 1-difluoro-2, 2-diarylethanes from arenes and fluorinated hemiacetals in the BF3–H2O system is described. The reaction is simple, clean, and convenient, eliminating the use of organic solvents and other expensive acid systems. BF3–H2O is economic, is easy to prepare, and offers ample acidity required for this reaction.

Related Articles:

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

[Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486]

The reduction of aryl trifluoromethyl ketones by sodium borohydride. The hydride transfer process

[Stewart, Ross; Teo, K. C. Canadian Journal of Chemistry, 1980 , vol. 58, p. 2491 - 2496]

More Articles...