Journal of Medicinal Chemistry 1976-02-01

Cycloalkanones. 8. Hypocholesterolemic activity of long-chain ketones related to pentadecanone.

S D Wyrick, I H Hall, C Piantadosi, C R Fenske

Index: J. Med. Chem. 19(2) , 219-22, (1976)

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Abstract

Aliphatic analogs of 2,8-dibenzylcyclooctanone which includes C15-C18 ketones have been investigated for hypocholesterolemic activity in rats. The position of the carbonyl group in the chain for maximum activity appears to be the 2 position. 2-Hexadecanone reduced serum cholesterol levels significantly without altering serum triglyceride levels. This drug was not estrogenic at effective doses which is in contrast to the cyclooctanones which possess this activity.

Related Compounds

  • 2-Hexadecanone

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