Synthesis of. beta.-keto esters by the Reformatsky reaction of 3-acyloxazolidin-2-ones and-thiazolidine-2-thiones

C Kashima, XC Huang, Y Harada…

Index: Kashima, Choji; Huang, Xin Cheng; Harada, Yukari; Hosomi, Akira Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 793 - 794

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Citation Number: 22

Abstract

As organozinc reagents are essentially unreactive toward ester carbonyl groups,@-hydroxy esters have been prepared conveniently via the Reformatsky reaction, wherein a-halo esters react with aldehydes and ketones in the presence of zinc.'However, the direct synthesis of@- keto esters via the Reformatsky reaction with esters and other carboxylic acid derivatives has never been reported, owing to this property of organozinc compounds. Recently it was ...

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