Bioorganic & Medicinal Chemistry Letters 2007-06-15

Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

Bao Teng, Yunpeng Bai, Yu Chang, Shizhen Chen, Zhaolong Li

Index: Bioorg. Med. Chem. Lett. 17 , 3440, (2007)

Full Text: HTML

Abstract

The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.

Related Compounds

  • Tricine
  • 4,4'-Dimethoxytrit...

Related Articles:

Anaphylaxis induced by a drug containing lysozyme and papain: influence of papain on the IgE response.

2014-01-01

[Int. Arch. Allergy Immunol. 165(2) , 83-90, (2014)]

Aeromonas piscicola AH-3 expresses an extracellular collagenase with cytotoxic properties.

2015-03-01

[Lett. Appl. Microbiol. 60(3) , 288-97, (2015)]

Solubilization of gliadins for use as a source of nitrogen in the selection of bacteria with gliadinase activity.

2015-02-01

[Food Chem. 168 , 439-44, (2014)]

A novel strategy for the discrimination of gelatinous Chinese medicines based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detection.

2015-01-01

[Int. J. Nanomedicine 10 , 4947-55, (2015)]

PeBL1, a novel protein elicitor from Brevibacillus laterosporus strain A60, activates defense responses and systemic resistance in Nicotiana benthamiana.

2015-04-01

[Appl. Environ. Microbiol. 81(8) , 2706-16, (2015)]

More Articles...