Journal of chromatography. B, Biomedical sciences and applications 1998-09-25

Beta2-adrenergic agonist residues: simultaneous methyl- and butylboronic derivatization for confirmatory analysis by gas chromatography-mass spectrometry.

F Ramos, C Santos, A Silva, M I da Silveira

Index: J. Chromatogr. B. Biomed. Sci. Appl. 716(1-2) , 366-70, (1998)

Full Text: HTML

Abstract

A derivatization procedure for confirmatory residue analysis of beta2-agonists is described. Methyl (MBA) and butyl (BBA) boronic acids are simultaneously used for the derivatization of tulobuterol, mabuterol, mapenterol, salbutamol, clenproperol, clenbuterol, clenpenterol and bromobuterol by GC-MS determination. A temperature of 55 degrees C during 60 min was selected as optimal temperature-time condition for simultaneous MBA and BBA beta2-agonists derivatization. It was also observed that stability of boronic derivatives was maintained at -20 degrees C over a period of four days. The proposed methodology was tested in urine and it could be applied for confirmatory residue analysis of clenbuterol-like compounds.

Related Compounds

  • 1-Butaneboronic ac...

Related Articles:

Inhibitors of bacterialN-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity

2009-01-01

[Bioorg. Med. Chem. Lett. 19 , 6350-2, (2009)]

n-Alkylboronic acid inhibitors reveal determinants of ligand specificity in the quorum-quenching and siderophore biosynthetic enzyme PvdQ.

2014-10-28

[Biochemistry 53(42) , 6679-86, (2014)]

The use of low-energy collisionally activated dissociation negative-ion tandem mass spectrometry for the characterization of dog and human urinary metabolites of the drug BW 1370U87.

1994-03-01

[Rapid Commun. Mass Spectrom. 8(3) , 265-73, (1994)]

Measurement of myo-inositol in diabetic sera by GC/MS/SIM using n-butylboronate derivatives.

1988-08-31

[Clin. Chim. Acta 176(2) , 207-12, (1988)]

A transition-state-analog inhibitor influences zinc-binding by Aeromonas aminopeptidase.

1985-08-15

[Biochem. Biophys. Res. Commun. 130(3) , 1154-60, (1985)]

More Articles...