Synthese von (Methylthio) penam??Derivaten durch Keten??Addition an 4, 5??Dihydro??5??(methylthio)??1, 3??thiazole

…, R Prewo, JH Bieri, H Heimgartner

Index: Jenny, Christjohannes; Heimgartner, Heinz Helvetica Chimica Acta, 1986 , vol. 69, p. 374 - 388

Full Text: HTML

Citation Number: 4

Abstract

The 4, 5-dihydro-5-(methyIthio)-2-phenyl-1, 3-thiazoles 3a and 3b, easily prepared from the corresponding 1, 3-thiazol-5 (4H)-thiones and MeLi, react with dichloroacetyl chloride (5a) and acidoacetyl chloride (5b) in the presence of Et, N to give (methy1thio) penam derivatives 6 (Table 1). The reaction mechanism is either a [2+ 21 cycloaddition of in situ generated ketene or a two-step reaction (Scheme 2). The structure of 6f has been confirmed by X-ray ...

Related Articles:

Studies into the synthesis of derivatives of 4-amino-2, 3-dihydroisothiazole 1, 1-dioxides and 4-amino-1, 2-oxathiole 2, 2-dioxides: The search for linked π-system …

[Ingate, Simon T.; Marco, Jose L.; Witvrouw, Myriam; Pannecouque, Cristophe; De Clercq, Erik Tetrahedron, 1997 , vol. 53, # 52 p. 17795 - 17814]

Structural modifications of 5, 6-dihydroxypyrimidines with anti-HIV activity

[Guo, Di-Liang; Zhang, Xing-Jie; Wang, Rui-Rui; Zhou, Yu; Li, Zeng; Xu, Jin-Yi; Chen, Kai-Xian; Zheng, Yong-Tang; Liu, Hong Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7114 - 7118]

Regioselectivity of the photochemical addition of ammonia, phosphine, and silane to olefinic and acetylenic nitriles

[Chemistry - A European Journal, , vol. 4, # 6 p. 1074 - 1082]

More Articles...