Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups

…, F Sakamoto, Y Inoue, G Tsukamoto

Index: Kondo, Hirosato; Sakamoto, Fumio; Inoue, Yoshimasa; Tsukamoto, Goro Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 679 - 682

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Citation Number: 15

Abstract

MCPBA= m-chloroperbenzoic acid. bIsolated yield. Starting material. drt= room temperature.'N-Oxide should be produced but in IC (6 3.32). The 'H NMR spectrum of 5c exhibited signals for four methylene protons of the piperazine moiety as doublets at 3.59 ppm (2 H) and 3.86 ppm (2 H) and as triplets at 4.03 ppm (2 H) and 4.23 ppm (2 H). The mass it could not be isolated. terized by 'H NMR analysis and mass spectrometry (Table ...

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