Dichloromethane activation. Direct methylenation of ketones and aldehydes with CH2Cl2 promoted by Mg/TiCl4/THF.

Tu-Hsin Yan, Chia-Chung Tsai, Ching-Ting Chien, Chia-Ching Cho, Pei-Chen Huang

Index: Org. Lett. 6(26) , 4961-3, (2004)

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Abstract

[reaction: see text] This Mg-TiCl4-promoted CH2-transfer reaction of CH2Cl2 represents an extremely simple, practical, and efficient methylenation of a variety of ketones and aldehydes, especially in enolizable or sterically hindered ketones such as 2,2-dimethylcyclohexanone, camphor, and fenchone.