Fast Halogenation of Some N??Heterocycles by Means of N, N′??Dihalo??5, 5??dimethylhydantoin

AH Sandtorv, HR Bjørsvik

Index: Sandtorv, Alexander H.; Bjorsvik, Hans-Rene Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 499 - 507

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Citation Number: 15

Abstract

Abstract An instantaneous, selective and high-yielding halogenation process is reported. The method operates with imidazoles, pyrazoles, and indoles under benign reaction conditions. The developed process involves the use of N, N′-dihalo-5, 5- dimethylhydantoins (halo= chlorine, bromine, iodine) as halogenation reagents that are activated by catalytic quantities of a strong Brønsted acid. Moreover, the halogenation ...