Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222

D Ren, L Li, AW Schwabacher, JW Young, DC Beitz

Index: Ren, Dewei; Li, Ling; Schwabacher, Alan W.; Youbg, Jerry W.; Beitz, Donald C. Steroids, 1996 , vol. 61, # 1 p. 33 - 40

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Citation Number: 45

Abstract

The mechanism of reduction of cholesterol to coprostanol by Eubacterium coprostanoligenes ATCC 51222 was studied by incubating the bacterium with a mixture of α- and β-isomers of [4-3H, 4-14C] cholesterol. Coprostanol, isolated after incubation of [4-3H, 4- 14C] cholesterol in a growth medium under anaerobic conditions, retained 97% of the tritium originally present in cholesterol. The majority of this tritium (64%), however, was in the C-6 ...