Bioorganic & Medicinal Chemistry Letters 2010-08-01

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity.

Theola Louie, C Dean Goodman, Georgina A Holloway, Geoffrey I McFadden, Vanessa Mollard, Keith G Watson

Index: Bioorg. Med. Chem. Lett. 20 , 4611-3, (2010)

Full Text: HTML

Abstract

A series of dimeric 1,3-cyclohexanedione oxime ethers were synthesized and found to have significant antiplasmodial activity with IC(50)'s in the range 3-12 microM. The most active dimer was tested in the Plasmodium berghei mouse model of malaria and at a dose of 48 mg/kg gave a 45% reduction in parasitaemia. Several commercial herbicides, all known to be inhibitors of maize acetyl-CoA carboxylase, were also tested for antimalarial activity, but were essentially inactive with the exception of butroxydim which gave an IC(50) of 10 microM.Copyright 2010 Elsevier Ltd. All rights reserved.

Related Compounds

  • quizalofop-ethyl
  • 1,3-Cyclohexanedio...

Related Articles:

Differential sensitivity of lipid metabolism in monocotyledons to grass-specific herbicides.

1993-05-01

[Biochem. Soc. Trans. 21(2) , 183S, (1993)]

Use of plant cell cultures to study graminicide effects on lipid metabolism.

2003-07-01

[Phytochemistry 63(5) , 533-41, (2003)]

Effects of water management and herbicide treatments on red rice control.

2002-01-01

[Meded. Rijksuniv. Gent. Fak. Landbouwkd. Toegep. Biol. Wet. 67(3) , 441-9, (2002)]

Enantioselectivity in degradation and transformation of quizalofop-ethyl in soils.

2012-07-01

[Chirality 24(7) , 552-7, (2012)]

Enzyme inhibitors to increase poly-3-hydroxybutyrate production by transgenic tobacco.

2002-12-01

[Biosci. Biotechnol. Biochem. 66(12) , 2537-42, (2002)]

More Articles...