Bioorganic & Medicinal Chemistry Letters 2007-02-15

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).

Abdelselam Ali, Marianne Bliese, Jo-Anne M Rasmussen, Roger M Sargent, Simon Saubern, David G Sawutz, John S Wilkie, David A Winkler, Kevin N Winzenberg, Ruth C J Woodgate

Index: Bioorg. Med. Chem. Lett. 17 , 993-7, (2007)

Full Text: HTML

Abstract

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.

Related Compounds

  • Closantel

Related Articles:

The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina.

2011-08-01

[Parasitol. Res. 109 Suppl 1 , S139-48, (2011)]

Emergency slaughter of casualty cattle increases the prevalence of anthelmintic drug residues in muscle.

2012-08-01

[Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(8) , 1263-71, (2012)]

An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

2012-01-05

[Toxicol. Lett. 208(1) , 30-5, (2012)]

Closantel toxicosis in kid goats.

2006-10-21

[Vet. Rec. 159(17) , 564-6, (2006)]

Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.

2014-07-10

[J. Med. Chem. 57(13) , 5792-9, (2014)]

More Articles...