Bioorganic & medicinal chemistry

Non-antibiotic antibacterial activity of dodecyl gallate

I Kubo, K Fujita, K Nihei, N Masuoka

Index: Kubo, Isao; Fujita, Ken-ichi; Nihei, Ken-ichi; Masuoka, Noriyoshi Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 4 p. 573 - 580

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Citation Number: 62

Abstract

Dodecyl (C12) gallate (3, 4, 5-trihydroxybenzoate)(1) was found to possess antibacterial activity specifically against Gram-positive bacteria, in addition to its potent antioxidant activity. The time–kill curve study indicates that this amphipathic gallate exhibits bactericidal activity against methicillin resistant Staphylococcus aureus (MRSA) strains. Dodecyl (lauryl) gallate inhibited oxygen consumption in whole cells and oxidation of NADH in membrane ...