Bioorganicheskaia khimiia 2011-01-01

[Synthesis and antitumor activity of betulin, erythrodiol and uvaol aminopropoxy derivatives].

O B Kazakova, G V Giniiatullina, G A Tolstikov, I P Baĭkova, L Zaprutko, G N Apryshko

Index: Bioorg. Khim. 37(3) , 414-24, (2011)

Full Text: HTML

Abstract

The synthesis of aminopropoxy derivatives of betulin, erythrodiol, uvaol and oleantriol via cyanoethylation of triterpenoids hydroxyl groups and subsequent reduction of cyanoethyl fragments is described. High and specific in vitro antitumor activity (cytotoxicity) of 3beta,28-di-O-[3-(aminopropoxy)]lupa-20(29)-ene and 3beta-O-hydroxy-28-O-[3-(aminopropoxy)]olean-12-ene towards a wide range of human tumor cell lines is discovered. The aminopropoxy group is shown to be a new perspective pharmacophor group for design of anticancer agents on the basis of triterpenoids.

Related Compounds

  • Erythrodiol
  • Uvaol
  • Betulin

Related Articles:

Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta.

2004-10-01

[Br. J. Nutr. 92(4) , 635-42, (2004)]

Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector.

2012-01-01

[J. AOAC Int. 95(6) , 1720-4, (2012)]

Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.

2006-12-01

[Cytokine 36(5-6) , 211-7, (2006)]

Characterisation and phenolic profiles of two rare olive oils from southern Tunisia: Dhokar and Gemri-Dhokar cultivars.

2013-02-01

[J. Sci. Food Agric. 93(3) , 527-34, (2013)]

Quality and chemical profiles of monovarietal north Moroccan olive oils from "Picholine Marocaine" cultivar: registration database development and geographical discrimination.

2015-07-15

[Food Chem. 179 , 127-36, (2015)]

More Articles...