Journal of Natural Products 2011-10-28

Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark.

Damien Lacroix, Soizic Prado, Dennis Kamoga, John Kasenene, Bernard Bodo

Index: J. Nat. Prod. 74 , 2286-9, (2011)

Full Text: HTML

Abstract

From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.

Related Compounds

  • Campathecin
  • Trigonelline chlor...

Related Articles:

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity.

2014-09-30

[Oncotarget 5(18) , 8107-22, (2014)]

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

2014-07-21

[J. Cell Biol. 206(2) , 183-97, (2014)]

A dihydroselenoquinazoline inhibits S6 ribosomal protein signalling, induces apoptosis and inhibits autophagy in MCF-7 cells.

2014-10-15

[Eur. J. Pharm. Sci. 63 , 87-95, (2014)]

Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism.

2015-01-01

[BMC Cancer 15 , 139, (2015)]

The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis.

2015-07-03

[Toxicology 333 , 37-44, (2015)]

More Articles...