Study of regioselective methanesulfonylation of simple aromatics with methanesulfonic anhydride in the presence of zeolite catalysts.

Keith Smith, Gordon M Ewart, Gamal A El-Hiti, Kenneth R Randles

Index: Org. Biomol. Chem. 2(21) , 3150-4, (2004)

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Abstract

Regioselective methanesulfonylation of simple aromatics using methanesulfonic anhydride can be achieved over zeolite catalysts. For example, methanesulfonylation of toluene over various cation-exchanged zeolite beta catalysts affords higher para-selectivity in the synthesis of methyl tolyl sulfone than standard Friedel-Crafts methanesulfonylation utilising aluminium chloride.