Reactivity of auranofin with selenols and thiols–implications for the anticancer activity of gold (I) compounds

F Di Sarra, B Fresch, R Bini, G Saielli…

Index: Di Sarra, Francesca; Fresch, Barbara; Bini, Riccardo; Saielli, Giacomo; Bagno, Alessandro European Journal of Inorganic Chemistry, 2013 , # 15 p. 2718 - 2727

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Citation Number: 6

Abstract

Abstract The enzyme thioredoxin reductase (TrxR) is attracting much interest as a potential target for cancer therapy. The presence of a selenium atom in the catalytic site makes it sensitive to inhibition by electrophilic molecules, including the Au I complex auranofin [2, 3, 4, 6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-S-(triethylphosphane) gold]. The reactions between auranofin and models of thiol and selenol nucleophiles present in TrxR (PhSH ...