An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of …

BL Renard, B Boucherle, B Maurin, MC Molina…

Index: Renard, Brice-Loic; Boucherle, Benjamin; Maurin, Bruno; Molina, Marie-Carmen; Norez, Caroline; Becq, Frederic; Decout, Jean-Luc European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1935 - 1941

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Citation Number: 4

Abstract

In the study of previously reported modulators of CFTR chloride channels that are cyclic methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a new expeditious one pot route for preparing in water novel aromatic polycyclic azaheterocycles and described 5-pyrimidinols antioxidants through the formation of 2- oxoaldehyde diadducts to aromatic α-aminoazaheterocycles, amidines, guanidines and ...

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