Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1997-09-01

Effect of 3-amino-1-propanol on the phosphatidylinositol (PI) and glycosyl phosphatidylinositol (GPI) systems of Tetrahymena.

P Kovács, L Kõhidai, G Csaba

Index: Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 118(1) , 83-7, (1997)

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Abstract

3-Amino-1-propanol (AP), a substance replacing ethanolamine in phosphatidylethanolamine (PE) significantly reduced 32P incorporation to phosphatidylinositol (PI) and glycosyl-phosphatidylinositol (GPI) in the unicellular organism Tetrahymena pyriformis. At 10 mM, AP completely inhibited the incorporation of 32P into PI. 3H-arachidonate incorporation into PI was also inhibited, while that into diacylglycerol (DAG) was high. The experiments indicate the presence and metabolism of inositol phospholipids and GPI in T. pyriformis.

Related Compounds

  • 3-Aminopropan-1-ol

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