Preparation of indoles from o-alkynyltrifluoroacetanilides through the aminopalladation-reductive elimination process

S Cacchi, G Fabrizi, LM Parisi

Index: Cacchi, Sandro; Fabrizi, Giancarlo; Parisi, Luca M. Synthesis, 2004 , # 11 p. 1889 - 1894

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Citation Number: 10

Abstract

Abstract The functionalized pyrrole nucleus contained in the indole system has been assembled via the palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with organic halides/triflates or allyl carbonates. In the presence of carbon monoxide, a three-component reaction can take place and indole derivatives incorporating a molecule of carbon monoxide have been obtained.