Tetrahedron

Copper on iron promoted one-pot synthesis of β-aminoenones and 3, 5-disubstituted pyrazoles

S Kovács, Z Novák

Index: Kovacs, Szabolcs; Novak, Zoltan Tetrahedron, 2013 , vol. 69, # 43 p. 8987 - 8993

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Citation Number: 8

Abstract

Abstract The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.

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