Inhibitors of blood platelet aggregation. Activity of some 1H-benz [de] isoquinolinecarboximidamides on the in vivo blood platelet aggregation induced by collagen

…, DG Meuleman, JH Wieringa

Index: Beetz, Tom; Meuleman, Dick G.; Wieringa, Joop H. Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 714 - 719

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Citation Number: 12

Abstract

A series of 33 1H-benz [de] isoquinolinecarboximidamides has been prepared and tested in the rat after intraperitoneal (ip) and/or oral (PO) administration for their ability to inhibit the in vivo blood platelet aggregation induced by collagen. In this aggregation test, a considerable number of active compounds were found. Fourteen compounds were active when administered ip [0.2 (mmol/kg)/day], five of which also exhibited significant PO activity. ...

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