Synthetic approaches to 1-(2-chlorophenyl) isoquinoline-3-carboxylic acid

YL Janin, E Roulland, A Beurdeley-Thomas…

Index: Janin, Yves L.; Roulland, Emmanuel; Beurdeley-Thomas, Arnaud; Decaudin, Didier; Monneret, Claude; Poupon, Marie-France Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 4 p. 529 - 532

Full Text: HTML

Citation Number: 9

Abstract

In connection with our research of new antitumor compounds, previously undescribed approaches to the 1-(2-chlorophenyl) isoquinoline-3-carboxylic acid 9 are reported here. Two related accesses from phenylethylamine or amphetamine were investigated and were found to be successful. A more robust synthesis, using Suzuki's cross-coupling between 2- chlorophenylboronic acid 15 and the previously unreported methyl-1-bromoisoquinoline-3 ...